Development of Methods of Quality Control of the Tablet «Ramipril»

Our main target was to develop methods for the quality control of tablet «ramipril» according indicators «Quantitative determination», «Impurities» and «Dissolution». New, precise, accurate green HPLC were developed determination ramipril its impurities in tablets. The separation accomplished using a diode array detector at 210 nm with an isocratic gradient mobile phase consisting 0.2 g/L solution sodium hexanesulfonate (pH 2.7) acetonitrile chromatographic columns Acclaim 120 C18 Inertsil ODS-3. method validated accordance ICH guidelines. analysis performed within run duration less than 25 min, which is about two times shorter that official Ph. Eur. method. tablets 4.5 three USP successfully applied In addition, they proved superiority over reported terms greenness different assessment tools.